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What Is Pleural Effusion?

Legally Reviewed by Joseph P. Williams on March 4, 2025

Pleural effusion is a condition where excess fluid builds up between the layers of the pleura, the thin membranes surrounding the lungs. This buildup can cause chest pain, difficulty breathing, and other serious complications, often linked to asbestos-related diseases like mesothelioma. 

At Williams Law Firm P.C., we understand the medical and financial challenges associated with conditions caused by asbestos exposure. Lead attorney Joseph P. Williams has never lost a mesothelioma case and has spent over 30 years fighting for victims’ rights, ensuring they receive the compensation needed for treatment and financial security.

What Is Pleural Effusion?

Pleural effusion is the gathering of fluid around the lungs in the lining between the lungs and the chest cavity. The pleural cavity is the space between the lungs and the chest wall where this fluid accumulates. The pleura is the thin membrane surrounding your lungs and the inside of the chest cavity. Effusion refers to an accumulation of fluid within the body. Pleural effusion is typically a symptom of a more serious illness rather than the illness itself. It is commonly associated with mesothelioma, a cancer that generally stems from exposure to asbestos. Living with pleural effusion can be difficult and require treatments to alleviate symptoms.

Definition and Overview

Pleural effusion is a medical condition characterized by the accumulation of excess fluid in the pleural space, the thin cavity between the lungs and the chest wall. Normally, this space contains a small amount of pleural fluid that acts as a lubricant, reducing friction between the lungs and the chest wall during breathing. However, when excess fluid builds up in the pleural space, it can lead to various symptoms and complications, making it difficult to breathe and causing discomfort.

Symptoms of Pleural Effusion

Another term for pleural effusion is water on the lung. It describes any excessive buildup of fluids in the lining of the lungs. While a small amount of fluid always exists in the pleura to help lubricate the lungs, too much fluid is dangerous. Pleural effusion is a common condition, affecting approximately one million new patients per year. It occurs most often when something irritates or inflames the pleura. Pleural effusion can lead to many different symptoms. Pleural effusion symptoms can vary widely, ranging from no noticeable signs to specific symptoms such as exertional breathlessness, cough, and fever.

  • Pain in your chest
  • Dry or persistent cough
  • Persistent hiccups
  • Shortness of breath
  • Trouble breathing while on your back
  • Trouble breathing during physical activity
  • Fever

The excess fluid in the chest cavity can press on the lungs and make it harder to breathe. If you notice any of these symptoms or sudden trouble breathing, consult a doctor about possible pleural effusion. Pleural effusion on its own is generally not life-threatening. As a symptom of a larger disease such as mesothelioma, however, it could point to more serious health concerns.

Types of Pleural Effusion

Pleural effusions can be broadly classified into two main types: transudative and exudative.

  • Transudative Pleural Effusions: These occur due to an imbalance in hydrostatic and oncotic pressures, leading to fluid accumulation in the pleural space. Common conditions associated with transudative effusions include congestive heart failure, liver disease, and kidney disease. In these cases, the pleural fluid is typically clear and low in protein.
  • Exudative Pleural Effusions: These are caused by inflammation or infection of the pleura, resulting in fluid buildup. Conditions such as pneumonia, tuberculosis, and cancer often lead to exudative effusions. The pleural fluid in these cases is usually cloudy and rich in proteins and other cellular components.

Understanding the type of pleural effusion is crucial for determining the underlying cause and appropriate treatment.

Diagnosis

Diagnosing pleural effusion involves a combination of clinical evaluation, imaging studies, and pleural fluid analysis. Each step provides critical information to pinpoint the cause and guide treatment.

History and Physical Examination

A thorough history and physical examination are the first steps in diagnosing pleural effusion. By discussing the patient’s symptoms and medical history, doctors can gather valuable clues about the potential cause of the effusion. During the physical examination, signs such as decreased breath sounds, dullness to percussion, and a pleural friction rub can indicate the presence of pleural effusion.

Imaging Studies

Imaging studies play a vital role in confirming pleural effusion. Chest X-rays, CT scans, and ultrasounds can reveal the presence, size, and location of the fluid buildup. These imaging techniques also help identify any underlying lung diseases that might be contributing to the effusion.

Pleural Fluid Analysis

Pleural fluid analysis is a key diagnostic tool for evaluating pleural effusion. By analyzing the pleural fluid, doctors can gain insights into the underlying cause of the effusion. The fluid is tested for various parameters, including protein, lactate dehydrogenase (LDH), and glucose levels. The presence of blood or pus in the fluid can indicate infection or malignancy, providing crucial information for diagnosis and treatment planning.

By following these diagnostic steps, healthcare providers can accurately diagnose pleural effusion and determine the best course of action for treatment.

Mesothelioma and Malignant Pleural Effusion

Pleural effusion could be a sign of an asbestos-related disease. Malignant pleural effusion (MPE) is often associated with cancers such as mesothelioma, and it signifies a poor prognosis due to its incurable nature. This might be the case if you have scar tissues accumulating on the pleura of the lungs from asbestos as a source of irritation. You might have scarring of the pleura from asbestos particles rubbing against the tissues and irritating them over time. The inflammation, scarring, and swelling from asbestos irritation could be enough to thicken the pleura and cause respiratory issues. Pleural thickening can worsen and spread to other parts of the lungs after each inundation of fluid.

A doctor may use chest x-rays, a physical exam to look for decreased chest movements, and other methods to diagnose pleural effusion. Combined with other symptoms, such as chest pain, fever, night sweats, fatigue, and muscle weakness, your pleural effusion could lead to a diagnosis of pleural mesothelioma. This is a type of cancer in the lungs, most often from asbestos exposure. Mesothelioma is usually terminal, although patients may be able to extend their lifespans and improve their quality of living with available treatments. Treatments may include medications or therapies to ease the effects of pleural effusion and other symptoms.

Pleural effusion could also point to other types of cancer spreading to the lining of the lungs. Cancer cells from lung, breast, ovarian, cervical, or uterine cancers could block the normal flow of fluids in the pleura. This can cause a buildup of excess fluids, along with symptoms of pleural effusion. Leukemia and melanoma could also cause pleural effusion, as can common cancer treatments such as chemotherapy and radiation therapy.

Is Pleural Effusion Treatable with Pleural Fluid Analysis?

Minor pleural effusions typically go away on their own, without the need for medical intervention or special treatments. Moderate to serious pleural effusions may require medical care to treat the underlying cause of the respiratory problem, such as antibiotics for an infection. If you have pleural effusion due to mesothelioma, it may be untreatable. Managing a malignant effusion often involves procedures like thoracocentesis for symptomatic relief and may include chemotherapy or radiation therapy to address the underlying cancer. However, a physician could recommend remedies to alleviate the accumulation of fluid in the lungs and enhance your breathing, such as draining the fluid, receiving pleurodesis, or undergoing surgery. See a doctor right away if you notice symptoms of pleural effusion for more information about your specific case, treatments, and prognosis. In the event mesothelioma caused your pleural effusion, explore your legal options with a qualified New York mesothelioma lawyer.

Legal Support for Asbestos-Related Illnesses

Pleural effusion can be an early sign of a serious asbestos-related illness, including mesothelioma. At Williams Law Firm P.C., we fight for individuals diagnosed with conditions caused by asbestos exposure, ensuring they receive the compensation they deserve. Lead attorney Joseph P. Williams has never lost a mesothelioma case, using his 30 years of experience to hold negligent asbestos manufacturers and employers accountable.

If you or a loved one has developed pleural effusion due to asbestos exposure, you may be entitled to financial compensation for medical expenses, lost wages, and pain and suffering. We provide dedicated legal representation and guidance to help you navigate your claim. Contact us today to learn how we can fight for you. Call (855) 575-6376 or reach out through our contact form.

Joseph P. Williams

Legally Reviewed by

Joseph P. Williams
Renowned Mesothelioma Attorney

March 4, 2025

As the founding partner of Williams Law Firm, Joseph P. Williams has dedicated over 30 years to representing mesothelioma victims and their families. His firm has recovered hundreds of millions of dollars for those affected by asbestos exposure, offering personalized, aggressive legal advocacy. Based in New York, Williams Law Firm provides free consultations and handles cases nationwide.

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